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Article

A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population.

Breast cancer research and treatment - 1 Apr 2011

Jiang Lan, Zhang Chun, Li Yinyan, Yu Xiao, Zheng Jian, Zou Ping, Li Yuting, Bin Xiaonong, Lu Jiachun, Zhou Yifeng

Abstract excerpt

As a tumor-associated antigen and a surface marker of breast cancer stem cells (BCSCs), epithelial cell adhesion molecule (EpCAM) plays an important role in not only cell adhesion, morphogenesis, metastases but also carcinogenesis. A non-synonymous C/T polymorphism (rs1126497) in exon3 of EpCAM causes a transition of 115 amino acid from Met to Thr. Another polymorphism (A/G, rs1421) in the 3'UTR causes loss of...

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PMID: 20683652
DOI: 10.1007/s10549-010-1094-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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