Article
Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification.
Analytical biochemistry - 1 Nov 1995
Doll M A, Fretland A J, Deitz A C, Hein D W
Abstract excerpt
The human N-acetylation polymorphism, encoded by the NAT2 gene locus, has been associated with higher incidence and/or severity to the adverse effects of therapeutic drugs, and to the carcinogenic actions of environmental and occupational chemicals. In this paper, we describe an efficient method...
Topics
- Acetylation
- Alleles
- Arylamine N-Acetyltransferase
- Base Sequence
- Genotype
- Humans
- Isoenzymes
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length