Article
Lethal pulmonary infection with Francisella novicida is associated with severe sepsis
28 Apr 2009
Abstract excerpt
The bacterial or host determinants of lethality associated with respiratory Francisella infections are currently unknown. No exo- or endotoxins that contribute to the severity of this disease have been identified. However, a deregulated host immune response upon infection is characterized by an initial 36- to 48-h delay followed by a rapid and excessive inflammatory response prior to death at 72-120 h. Here, we...
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