Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2.

Blood - 4 Nov 2010

Maes Ken, Nemeth Elizabeta, Roodman G David, Huston Alissa, Esteve Flavia, Freytes Cesar, Callander Natalie, Katodritou Eirini, Tussing-Humphreys Lisa, Rivera Seth, Vanderkerken Karin, Lichtenstein Alan, Ganz Tomas

Abstract excerpt

Hepcidin is the principal iron-regulatory hormone and a pathogenic factor in anemia of inflammation. Patients with multiple myeloma (MM) frequently present with anemia. We showed that MM patients had increased serum hepcidin, which inversely correlated with hemoglobin, suggesting that hepcidin contributes to MM-related anemia. Searching for hepcidin-inducing cytokines in MM, we quantified the stimulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia
Share to Antimicrobial Cationic Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Morphogenetic Protein 2

Share to Bone Morphogenetic Proteins

Share to Hemoglobins

Share to Hepcidins

Share to Multiple Myeloma

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 20679527
DOI: 10.1182/blood-2010-03-274571
PMCID: PMC2981483

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2.PMID 20679527Read ↗

Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genesSemantic proximity Read ↗

Transcriptome Analysis of Mesenchymal Stem Cells from Multiple Myeloma Patients Reveals Downregulation of Genes Involved in Cell Cycle Progression, Immune Response, and Bone MetabolismSemantic proximity Read ↗

Myeloma cell–derived Runx2 promotes myeloma progression in boneSemantic proximity Read ↗

AML-1A and AML-1B regulation of MIP-1α expression in multiple myelomaSemantic proximity Read ↗

The systemic cytokine environment is permanently altered in multiple myeloma.Semantic proximity Read ↗

Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYCSemantic proximity Read ↗

Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies.Semantic proximity Read ↗

Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype.Semantic proximity Read ↗

Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone lossSemantic proximity Read ↗

Allelic mutations in noncoding genomic sequences construct novel transcription factor binding sites that promote gene overexpression.Semantic proximity Read ↗

Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 TranscriptionSemantic proximity Read ↗

Association of IL-6 Promoter and Receptor Polymorphisms with Multiple Myeloma Risk: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.