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Myeloma cell–derived Runx2 promotes myeloma progression in bone

11 Apr 2015

Abstract excerpt

The progression of multiple myeloma (MM) is governed by a network of molecular signals, the majority of which remain to be identified. Recent studies suggest that Runt-related transcription factor 2 (Runx2), a well-known bone-specific transcription factor, is also expressed in solid tumors, where expression promotes both bone metastasis and osteolysis. However, the function of Runx2 in MM remains unknown. The...

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PMID: 25862559
DOI: 10.1182/blood-2014-12-613968

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