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Article

Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness.

The Journal of experimental medicine - 30 Aug 2010

Pietzsch John, Scheid Johannes F, Mouquet Hugo, Klein Florian, Seaman Michael S, Jankovic Mila, Corti Davide, Lanzavecchia Antonio, Nussenzweig Michel C

Abstract excerpt

The identification and characterization of conserved epitopes on the HIV-1 viral spike that are immunogenic in humans and targeted by neutralizing antibodies is an important step in vaccine design. Antibody cloning experiments revealed that 32% of all HIV-neutralizing antibodies expressed by the...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HIV Envelope Protein gp120

Share to Protein Structure, Tertiary

Source

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Identifiers

PMID: 20679402
DOI: 10.1084/jem.20101176
PMCID: PMC2931156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20679402-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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