Article
Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene.
Human genetics - 1 Oct 2010
Chen Zhiyong, Nakajima Toshiaki, Tanabe Nobuhiro, Hinohara Kunihiko, Sakao Seiichiro, Kasahara Yasunori, Tatsumi Koichiro, Inoue Yoshinori, Kimura Akinori
Abstract excerpt
A deletion/insertion (Del/Ins) polymorphism of 28 base pairs (bp) in the 3' untranslated region (UTR) of fibrinogen alpha gene (FGA) was associated with thromboembolic diseases, but the underlying mechanisms remain unknown. Computational predication reveals that the 28 bp polymorphic fragment is...
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