Article
Functional polymorphisms of FGA, encoding alpha fibrinogen, are associated with susceptibility to venous thromboembolism in a Taiwanese population.
Human genetics - 1 Mar 2006
Ko Yu-Lin, Hsu Lung-An, Hsu Tsu-Shiu, Tsai Chia-Ti, Teng Ming-Sheng, Wu Semon, Chang Chi-Jen, Lee Ying-Shiung
Abstract excerpt
To determine the genetic risk factors for venous thromboembolism (VTE), this study examined 14 genetic variants from 10 hemostatic genes in 186 Taiwanese VTE patients and the same number of matched controls, which demonstrated FGA (encoding alpha fibrinogen) Thr312Ala polymorphism was the only variant significantly associated with VTE. Nine genetic polymorphisms on the fibrinogen cluster region of chromosome 4q28...
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