Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fibrinogen Aα Thr312Ala polymorphism specifically contributes to chronic thromboembolic pulmonary hypertension by increasing fibrin resistance.

PloS one - 1 Jan 2013

Li Ji-Feng, Lin Yuan, Yang Yuan-Hua, Gan Hui-Li, Liang Yan, Liu Jie, Yang Su-Qiao, Zhang Wei-Juan, Cui Na, Zhao Lan, Zhai Zhen-Guo, Wang Jun, Wang Chen

Abstract excerpt

BACKGROUND: Polymorphisms are associated with chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary thromboembolism (PTE), but no polymorphism specific to CTEPH but not PTE has yet been reported. Fibrin resistance is associated with CTEPH, but the mechanism has not been elucidated. METHODS: Polymorphisms were analyzed in 101 CTEPH subjects, 102 PTE subjects and 108 healthy controls by Massarray or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Chronic Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrin

Share to Fibrinogen

Share to Fibrinolysis

Share to Hypertension, Pulmonary

Share to Pulmonary Embolism

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 23894515
DOI: 10.1371/journal.pone.0069635
PMCID: PMC3718692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fibrinogen Aα Thr312Ala polymorphism specifically contributes to chronic thromboembolic pulmonary hypertension by increasing fibrin resistance.PMID 23894515Read ↗

Molecular Research in Chronic Thromboembolic Pulmonary HypertensionSemantic proximity Read ↗

High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension.Semantic proximity Read ↗

Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension.Semantic proximity Read ↗

Genetic and Clinical Determinants of Chronic Thromboembolic Pulmonary Hypertension: The Role of PAI-1 Polymorphism.Semantic proximity Read ↗

A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axisSemantic proximity Read ↗

The incidence of the thrombophilic SNPs rs6025, rs1799963, rs2066865, rs2289252, and rs8176719 in chronic thromboembolic pulmonary hypertension.Semantic proximity Read ↗

Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene.Semantic proximity Read ↗

The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study.Semantic proximity Read ↗

Fibrinogen β chain and FXIII polymorphisms affect fibrin clot properties in acute pulmonary embolismSemantic proximity Read ↗

BHMT polymorphism and susceptibility to PTE in Chinese patients.Semantic proximity Read ↗

Potential Risk Factors Associated With Vascular Diseases in Patients Receiving Treatment for Hypertension.Semantic proximity Read ↗

Thrombin-Activatable Fibrinolysis Inhibitor in Chronic Thromboembolic Pulmonary Hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.