Article

Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair Capacity

2024-07-17

Abstract excerpt

BRAF and MEK inhibitors (BRAF/MEKi) have radically changed the treatment landscape of advanced BRAF mutation-positive tumours. However, limited efficacy and emergence of drug resistance are major handicaps for successful treatments. Here, by using relevant preclinical models, we found that Connexin43 (Cx43), a protein that plays a role in cell-to-cell communication, increases effectiveness of BRAF/MEKi by recruiti...

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Literature Corpus work: eae8fb2e-7ac4-5a9c-a6bf-9c1ee9855514
DOI: 10.1101/2024.07.15.601645

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