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Article

Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia

1 Oct 2010

Abstract excerpt

BACKGROUND: Methylation of tumor suppression genes (TSGs) is common in myeloid malignancies. However, application of this as a molecular marker for risk stratification in patients with AML is limited. DESIGN AND METHODS: To elucidate the impact of patterns of TSG methylation on outcome in cytogenetically normal patients, 106 samples from patients with having normal cytogenetic AML were evaluated for methylation...

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PMID: 20671427
DOI: 10.4161/epi.5.7.12558

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