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Article

Promoter DNA methylation and expression levels of HOXA4, HOXA5 and MEIS1 in acute myeloid leukemia.

Molecular medicine reports - 1 May 2015

Musialik Ewa, Bujko Mateusz, Kober Paulina, Grygorowicz Monika Anna, Libura Marta, Przestrzelska Marta, Juszczyński Przemysław, Borg Katarzyna, Florek Izabela, Jakóbczyk Małgorzata, Siedlecki Janusz Aleksander

Abstract excerpt

HOXA genes encode transcription factors, which are crucial for embryogenesis and tissue differentiation and are involved in the early stages of hematopoiesis. Aberrations in HOXA genes and their cofactor MEIS1 are found in human neoplasms, including acute myeloid leukemia (AML). The present study investigated the role of HOXA4, HOXA5 and MEIS1 promoter DNA methylation and mRNA expression in AML. Samples from 78...

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Source

Identifiers

PMID: 25585874
DOI: 10.3892/mmr.2015.3196

Genes

HOXA4
MEIS1
HOXA5
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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