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Article

DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia.

PloS one - 16 Aug 2010

Alvarez Sara, Suela Javier, Valencia Ana, Fernández Agustín, Wunderlich Mark, Agirre Xabier, Prósper Felipe, Martín-Subero José Ignacio, Maiques Alba, Acquadro Francesco, Rodriguez Perales Sandra, Calasanz María José, Roman-Gómez Jose, Siebert Reiner, Mulloy James C, Cervera José, Sanz Miguel Angel, Esteller Manel, Cigudosa Juan C

Abstract excerpt

BACKGROUND: Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemia (AML) pathophysiology. However, further studies to discuss the prognostic value and the relationship of the epigenetic signatures with defined genomic rearrangements in acute myeloid leukemia are...

Read the complete abstract on PubMed

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Share to Chromosomes, Human
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Karyotyping

Share to Leukemia, Myeloid, Acute

Share to Oncogene Proteins, Fusion

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Share to Tumor Suppressor Proteins

Source

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Identifiers

PMID: 20808941
DOI: 10.1371/journal.pone.0012197
PMCID: PMC2922373

Genes

CBFB
MYH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20808941-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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