Article
Frequency of hemochromatosis gene (HFE) mutations in Russian healthy women and patients with estrogen-dependent cancers.
Biochimica et biophysica acta - 1 Jan 2006
Kondrashova Tatiana V, Neriishi Kazuo, Ban Sadayuki, Ivanova Tatiana I, Krikunova Lyudmila I, Shentereva Nataliya I, Smirnova Iya A, Zharikova Irina A, Konova Marina V, Taira Senjun, Tsyb Anatoly F
Abstract excerpt
Possible association between the C282Y and H63D mutations in the HFE gene and estrogen-dependent cancer risk was assessed. Genotyping was performed using PCR amplification followed by digestion of products with specific restrictases. In a population of 260 healthy women (permanent residents of the southwest European Russia), mutant allele frequencies at the C282Y and H63D sites were evaluated as 3.3 and 16.3%,...
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