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Article

Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate.

American journal of obstetrics and gynecology - 1 Aug 2011

Manuck Tracy A, Lai Yinglei, Meis Paul J, Dombrowski Mitchell P, Sibai Baha, Spong Catherine Y, Rouse Dwight J, Durnwald Celeste P, Caritis Steve N, Wapner Ronald J, Mercer Brian M, Ramin Susan M

Abstract excerpt

OBJECTIVE: Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB. STUDY DESIGN: We conducted secondary analysis of a study of 17-OHPC vs placebo for recurrent PTB prevention. Twenty PGR gene single nucleotide...

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Identifiers

PMID: 21600550
DOI: 10.1016/j.ajog.2011.03.048
PMCID: PMC3210889

Genes

PGR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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