Article
SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.
PloS one - 23 Jul 2010
Akieda-Asai Sayaka, Zaima Nobuhiro, Ikegami Koji, Kahyo Tomoaki, Yao Ikuko, Hatanaka Takahiro, Iemura Shun-Ichiro, Sugiyama Rika, Yokozeki Takeaki, Eishi Yoshinobu, Koike Morio, Ikeda Kyoji, Chiba Takuya, Yamaza Haruyoshi, Shimokawa Isao, Song Si-Young, Matsuno Akira, Mizutani Akiko, Sawabe Motoji, Chao Moses V, Tanaka Masashi, Kanaho Yasunori, Natsume Tohru, Sugimura Haruhiko, Date Yukari, McBurney Michael W, Guarente Leonard, Setou Mitsutoshi
Abstract excerpt
BACKGROUND: SIRT1, a NAD-dependent deacetylase, has diverse roles in a variety of organs such as regulation of endocrine function and metabolism. However, it remains to be addressed how it regulates hormone release there. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report that SIRT1 is abundantly expressed in pituitary thyrotropes and regulates thyroid hormone secretion. Manipulation of SIRT1 level revealed that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.