Article
CX3CR1 polymorphisms are associated with atopy but not asthma in German children.
International archives of allergy and immunology - 1 Jan 2007
Depner Martin, Kormann Michael S D, Klopp Norman, Illig Thomas, Vogelberg Christian, Weiland Stephan K, von Mutius Erika, Combadière Christophe, Kabesch Michael
Abstract excerpt
Chemokines and their receptors are involved in many aspects of immunity. Chemokine CX3CL1, acting via its receptor CX3CR1, regulates monocyte migration and macrophage differentiation as well as T cell-dependent inflammation. Two common, nonsynonymous polymorphisms in CX3CR1 have previously been shown to alter the function of the CX3CL1/CX3CR1 pathway and were suggested to modify the risk for asthma. Using...
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