Article
New insights into mechanisms of small vessel disease stroke from genetics.
Clinical science (London, England : 1979) - 1 Apr 2017
Tan Rhea, Traylor Matthew, Rutten-Jacobs Loes, Markus Hugh
Abstract excerpt
Cerebral small vessel disease (SVD) is a common cause of lacunar strokes, vascular cognitive impairment (VCI) and vascular dementia. SVD is thought to result in reduced cerebral blood flow, impaired cerebral autoregulation and increased blood-brain barrier (BBB) permeability. However, the molecular mechanisms underlying SVD are incompletely understood. Recent studies in monogenic forms of SVD, such as cerebral...
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