Article
Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates.
Virology - 10 Oct 2010
Schaap-Nutt Anne, D'Angelo Christopher, Amaro-Carambot Emerito, Nolan Sheila M, Davis Stephanie, Wise Shenelle-Marie, Higgins Caraline, Bradley Konrad, Kim Olivia, Mayor Reina, Skiadopoulos Mario H, Collins Peter L, Murphy Brian R, Schmidt Alexander C
Abstract excerpt
The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 virus in which P and V are expressed from separate genes (rHPIV2-P+V). rHPIV2-P+V replicated like HPIV2-WT in vitro and in non-human primates. HPIV2-P+V was modified by...
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