Article
Identification of amino acids essential for the human parainfluenza type 2 virus V protein to lower the intracellular levels of the STAT2.
Virology - 20 Dec 2003
Kozuka Yuji, Yamashita Yasufumi, Kawano Mitsuo, Tsurudome Masato, Ito Morihiro, Nishio Machiko, Komada Hiroshi, Ito Yasuhiko
Abstract excerpt
The V protein of SV41 targets STAT1, while a specific loss of STAT2 is induced by the hPIV2 V protein. We established HeLa cells constitutively expressing various chimeric proteins between the hPIV2 and SV41 V proteins, and which STAT (STAT1 or 2) was expressed in these cells was analyzed. Both the P-V common domain and the V specific domain of hPIV2 V protein are necessary for STAT2 lowering. The internal domain...
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