Article
Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains.
Archives of virology - 1 Nov 2021
Binder Florian, Gallo Giulia, Bendl Elias, Eckerle Isabella, Ermonval Myriam, Luttermann Christine, Ulrich Rainer G
Abstract excerpt
The orthohantavirus Puumala virus (PUUV), which is transmitted by bank voles (Clethrionomys glareolus), and other vole-borne hantaviruses contain in their small (S) genome segment two overlapping open reading frames, coding for the nucleocapsid protein and the non-structural protein NSs, a putative type I interferon (IFN-I) antagonist. To investigate the role of NSs of PUUV and other orthohantaviruses, the...
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