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Article

The role of M2 proteins of pneumoviruses in transcription regulation, prevention of hypermutation, and activation of the type I interferon pathway.

Journal of virology - 25 Feb 2025

Ribó-Molina Pau, Groen Kevin, Susma Balasubramanian, van Nieuwkoop Stefan, Funk Mathis, Fouchier Ron A M, van den Hoogen Bernadette G

Abstract excerpt

Human metapneumovirus (HMPV) is an important causative agent of respiratory tract disease. Fundamental knowledge of the interaction between HMPV and the innate immune system could lead to the design of novel antiviral therapies. Previously, we demonstrated that HMPV M2-2 deletion mutants had hypermutated genomes and contained defective interfering particles (DIs), which are potent inducers of the IFN response....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39835813
DOI: 10.1128/jvi.01243-24
PMCID: PMC11852930

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