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Evidence against the Human Metapneumovirus G, SH, and M2-2 Proteins as Bona Fide Interferon Antagonists

17 Aug 2022

Abstract excerpt

Understanding the interaction between viruses and the innate immune response is one of the barriers to the design of antiviral therapies. Here, we investigated the role of the G, SH, and M2-2 proteins of HMPV as type I IFN antagonists. In contrast to other studies, no IFN-antagonistic functions could be observed for the G and SH proteins. HMPV with a deletion of the M2-2 protein did induce type I IFN production...

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Identifiers

PMID: 35975999
DOI: 10.1128/jvi.00723-22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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