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Article

Effect of ABCB1 C3435T Polymorphism on Pharmacokinetics of Antipsychotics and Antidepressants.

Basic & clinical pharmacology & toxicology - 1 Oct 2018

Saiz-Rodríguez Miriam, Belmonte Carmen, Román Manuel, Ochoa Dolores, Jiang-Zheng Carolina, Koller Dora, Mejía Gina, Zubiaur Pablo, Wojnicz Aneta, Abad-Santos Francisco

Abstract excerpt

P-glycoprotein, encoded by ABCB1, is an ATP-dependent drug efflux pump which exports substances outside the cell. Some studies described connections between C3435T polymorphism T allele and lower P-glycoprotein expression; therefore, homozygous T/T could show higher plasma levels. Our aim was to evaluate the effect of C3435T on pharmacokinetics of 4 antipsychotics (olanzapine, quetiapine, risperidone and...

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PMID: 29723928
DOI: 10.1111/bcpt.13031

Genes

ABCB1

Variants

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