Article
Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.
Blood - 18 Nov 2010
Harris Levelle D, Klatt Nichole R, Vinton Carol, Briant Judith A, Tabb Brian, Ladell Kristin, Lifson Jeffrey, Estes Jacob D, Price David A, Hirsch Vanessa M, Brenchley Jason M
Abstract excerpt
T cells that express the γδ T-cell receptor, which recognize microbial or stress-induced antigens, represent a minority of blood T cells but constitute a major proportion of intraepithelial lymphocytes in the gastrointestinal mucosa. As microbial products have been shown to translocate from the gastrointestinal tract into circulation in chronically HIV/Simian immunodeficiency virus (SIV)-infected individuals, we...
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