Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding the Role of Mucosal-Associated Invariant T-Cells in Non-human Primate Models of HIV Infection.

Frontiers in immunology - 1 Jan 2020

Barber-Axthelm Isaac M, Kent Stephen J, Juno Jennifer A

Abstract excerpt

Chronic HIV infection causes systemic immune activation and dysregulation, resulting in the impairment of most T-cell subsets including MAIT cells. Multiple human cohort studies demonstrate MAIT cells are selectively depleted in the peripheral blood and lymphoid tissues during HIV infection, with incomplete restoration during suppressive antiretroviral therapy. Because MAIT cells play an important role in mucosal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Disease
Share to Coinfection
Share to Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macaca mulatta

Share to Organ Specificity

Share to Simian Acquired Immunodeficiency Syndrome

Share to T-Lymphocyte Subsets

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 33013862
DOI: 10.3389/fimmu.2020.02038
PMCID: PMC7461791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding the Role of Mucosal-Associated Invariant T-Cells in Non-human Primate Models of HIV Infection.PMID 33013862Read ↗

Mucosa-Associated Invariant T Cells Are Systemically Depleted in Simian Immunodeficiency Virus-Infected Rhesus Macaques.Semantic proximity Read ↗

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection.Semantic proximity Read ↗

MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infectionSemantic proximity Read ↗

Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection.Semantic proximity Read ↗

Mucosal‐associated invariant T cells: A cryptic coordinator in HIV‐infected immune reconstitutionSemantic proximity Read ↗

The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection.Semantic proximity Read ↗

MAIT cells are minimally responsive to Mycobacterium tuberculosis within granulomas, but are functionally impaired by SIV in a macaque model of SIV and Mtb co-infectionSemantic proximity Read ↗

Walk on the wild side: SIV infection in African non-human primate hosts—from the field to the laboratorySemantic proximity Read ↗

Attrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-tuberculosis co-infection is associated with elevated levels of PD-1 expression.Semantic proximity Read ↗

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections.Semantic proximity Read ↗

Activation and <i>in vivo</i> evolution of the MAIT cell transcriptome in mice and humans reveals diverse functionalitySemantic proximity Read ↗

Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.