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Article

PKCδ regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis.

European journal of immunology - 1 Mar 2011

Guler Reto, Afshar Mona, Arendse Berenice, Parihar Suraj P, Revaz-Breton Melanie, Leitges Michael, Schwegmann Anita, Brombacher Frank

Abstract excerpt

The protein kinase C (PKC) family is involved in the regulation of many intracellular signalling pathways. Here, we report that the PKCδ isoform regulates IL-12p40/p70 production in macrophages and DC and that PKCδ deficiency in mice transforms the 129/Sv healer to a non-healer strain during cutaneous leishmaniasis. Leishmania major-infected PKCδ(-/-) 129/Sv mice developed a rapid increase in footpad swelling and...

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PMID: 21287553
DOI: 10.1002/eji.201040985

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PKCδ regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis.PMID 21287553Read ↗

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