Article
An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2010
Matsushima Yoshibumi, Kikkawa Yoshiaki, Takada Toyoyuki, Matsuoka Kunie, Seki Yuta, Yoshida Hisahiro, Minegishi Yoshiyuki, Karasuyama Hajime, Yonekawa Hiromichi
Abstract excerpt
Spontaneous mutant mice that showed high levels of serum IgE and an atopic dermatitis (AD)-like skin disease were found in a colony of the KOR inbred strain that was derived from Japanese wild mice. No segregation was observed between hyper-IgE-emia and dermatitis in (BALB/c x KOR mutant) N(2) mice, suggesting that the mutation can be attributed to a single recessive locus, which we designated adjm (atopic...
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