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Article

TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.

Human molecular genetics - 1 Dec 2005

Morlon Aurore, Munnich Arnold, Smahi Asma

Abstract excerpt

Activation of the NF-kappaB pathway by the TNF-receptor Edar (Ectodysplasin receptor) and its downstream adaptator Edaradd (Edar-associated death domain) is essential for the development of hair follicles, teeth, exocrine glands and other ectodermal derivatives. Dysfunction of Edar signalling causes hypohidrotic/anhidrotic ectodermal dysplasia (ED), a disorder characterized by sparse hair, lack of sweat glands...

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Share to Ectodermal Dysplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Tumor Necrosis Factor

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Source

Identifiers

PMID: 16251197
DOI: 10.1093/hmg/ddi405

Genes

TAB2
TRAF6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.PMID 16251197Read ↗

Functional studies for the TRAF6 mutation associated with hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases.Semantic proximity Read ↗

Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.Semantic proximity Read ↗

Gene defect in ectodermal dysplasia implicates a death domain adapter in development.Semantic proximity Read ↗

Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus.Semantic proximity Read ↗

A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component.Semantic proximity Read ↗

Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice.Semantic proximity Read ↗

Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.Semantic proximity Read ↗

Signaling and subcellular localization of the TNF receptor Edar.Semantic proximity Read ↗

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Semantic proximity Read ↗

EVER2 protein binds TRADD to promote TNF-α-induced apoptosis.Semantic proximity Read ↗

An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene.Semantic proximity Read ↗

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