Article
Two patients with chronic mucocutaneous candidiasis caused by TRAF3IP2 deficiency.
The Journal of allergy and clinical immunology - 1 Jul 2021
Shafer Samantha, Yao Yikun, Comrie William, Cook Sarah, Zhang Yu, Yesil Gözde, Karakoç-Aydiner Elif, Baris Safa, Cokugras Haluk, Aydemir Sezin, Kiykim Ayca, Ozen Ahmet, Lenardo Michael
Abstract excerpt
BACKGROUND: TRAF3 interacting protein 2 (TRAF3IP2) (Act1) is an adapter protein that interacts with IL-17R via its similar expression to fibroblast growth factor genes and IL-17R domain and coordinates 2 separate proinflammatory pathways following IL-17 cytokine stimulation. OBJECTIVE: We sought to elucidate the immunologic consequences of TRAF3IP2 homozygous mutations to improve treatments for immunodeficiency...
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