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Article

CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2012

Sønder Søren Ulrik, Paun Andrea, Ha Hye-Lin, Johnson Peter F, Siebenlist Ulrich

Abstract excerpt

Psoriasis is a relapsing skin disease characterized by abnormal keratinocyte proliferation and differentiation and by an influx of inflammatory immune cells. Recently, IL-17 cytokines have been strongly implicated as critical for the pathogenesis of this disease. IL-17A (also known as IL-17) and IL-17F are the signature cytokines of Th17 cells, but are also produced by innate cells, including γδ T cells present...

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Identifiers

PMID: 22581863
DOI: 10.4049/jimmunol.1103233
PMCID: PMC3370149

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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