Article
Lineage-specific restraint of pituitary gonadotroph cell adenoma growth.
PloS one - 25 Mar 2011
Chesnokova Vera, Zonis Svetlana, Zhou Cuiqi, Ben-Shlomo Anat, Wawrowsky Kolja, Toledano Yoel, Tong Yunguang, Kovacs Kalman, Scheithauer Bernd, Melmed Shlomo
Abstract excerpt
Although pituitary adenomas are usually benign, unique trophic mechanisms restraining cell proliferation are unclear. As GH-secreting adenomas are associated with p53/p21-dependent senescence, we tested mechanisms constraining non-functioning pituitary adenoma growth. Thirty six gonadotroph-derived non-functioning pituitary adenomas all exhibited DNA damage, but undetectable p21 expression. However, these...
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