Article
Molecular basis of pituitary oncogenesis.
Journal of neuro-oncology - 1 Jan 1999
Tada M, Kobayashi H, Moriuchi T
Abstract excerpt
Recent advances in the molecular biology has served to unveil the underlying genetic and epigenetic alterations in pituitary adenomas. Three nuclear transcriptional factors, AP-1, CREB, and Pit-1, which are targets of protein kinase C and A, appear to play critical roles in both neoplastic growth and hormone secretion in hormone-producing adenomas. The alteration of G proteins such as Gs and Gi2 is a direct cause...
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