Article
Allergic sensitization and exposure to ambient air pollution beginning early in life lead to a COPD-like phenotype in young adult mice.
Ecotoxicology and environmental safety - 1 Aug 2022
de Souza Xavier Costa Natália, Mirtes Teles Aila, de Brito Jôse Mára, de Barros Mendes Lopes Thaís, Calciolari Rossi Renata, Magalhães Arantes Costa Fernanda, Mangueira Saraiva-Romanholo Beatriz, Perini Adenir, Furuya Tatiane Katsue, Germán Murillo Carrasco Alexis, Matera Veras Mariana, Nascimento Saldiva Paulo Hilário, Chammas Roger, Mauad Thais
Abstract excerpt
The perinatal period and early infancy are considered critical periods for lung development. During this period, adversities such as environmental exposures, allergic sensitization, and asthma are believed to impact lung health in adulthood. Therefore, we hypothesized that concomitant exposure to allergic sensitization and urban-derived fine particulate matter (PM2.5) in the early postnatal period of mice would...
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