Article
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.
Science translational medicine - 5 Oct 2016
Cho Josalyn L, Ling Morris F, Adams David C, Faustino Lucas, Islam Sabina A, Afshar Roshi, Griffith Jason W, Harris Robert S, Ng Aylwin, Radicioni Giorgia, Ford Amina A, Han Andre K, Xavier Ramnik, Kwok William W, Boucher Richard, Moon James J, Hamilos Daniel L, Kesimer Mehmet, Suter Melissa J, Medoff Benjamin D, Luster Andrew D
Abstract excerpt
Despite systemic sensitization, not all allergic individuals develop asthma symptoms upon airborne allergen exposure. Determination of the factors that lead to the asthma phenotype in allergic individuals could guide treatment and identify novel therapeutic targets. We used segmental allergen challenge of allergic asthmatics (AA) and allergic nonasthmatic controls (AC) to determine whether there are differences...
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