Article
Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice.
American journal of respiratory and critical care medicine - 1 Aug 2011
van Rijt Leonie S, Vos Nanda, Willart Monique, Muskens Femke, Tak Paul P, van der Horst Corine, Hoogsteden Henk C, Lambrecht Bart N
Abstract excerpt
RATIONALE: Polysensitization of patients who are allergic is a common feature. The underlying immunologic mechanism is not clear. The maturation status of dendritic cells (DCs) is considered to be important for priming naive T cells in the draining lymph nodes. We hypothesized that chronic airway inflammation can induce an enhanced maturation of airway DCs and facilitate subsequent priming to neoallergens....
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