Article
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.
Developmental cell - 16 Feb 2010
Tian Ying, Yuan Lijun, Goss Ashley M, Wang Tao, Yang Jifu, Lepore John J, Zhou Diane, Schwartz Robert J, Patel Vickas, Cohen Ethan David, Morrisey Edward E
Abstract excerpt
Little is understood about the molecular mechanisms underlying the morphogenesis of the posterior pole of the heart. Here we show that Wnt2 is expressed specifically in the developing inflow tract mesoderm, which generates portions of the atria and atrio-ventricular canal. Loss of Wnt2 results in defective development of the posterior pole of the heart, resulting in a phenotype resembling the human congenital...
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