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Article

Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3.

Biophysical journal - 7 Jul 2010

Liang Xiangyang, Arunima A, Zhao Yingchu, Bhaskaran Rajagopalan, Shende Anuradha, Byrne Todd S, Fleeks Jeremy, Palmier Mark O, Van Doren Steven R

Abstract excerpt

The greater activity of MMP-12 than MMP-3 toward substrates from protein fibrils has been quantified. Why is MMP-12 the more active protease? We looked for behaviors associated with the higher activity of MMP-12 than MMP-3, using nuclear magnetic resonance to monitor backbone dynamics and residue...

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Identifiers

PMID: 20655856
DOI: 10.1016/j.bpj.2010.04.002
PMCID: PMC2895380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20655856-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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