Article
Hydration and packing along the folding pathway of SH3 domains by pressure-dependent NMR.
Biochemistry - 18 Apr 2006
Bezsonova Irina, Korzhnev Dmitry M, Prosser R Scott, Forman-Kay Julie D, Kay Lewis E
Abstract excerpt
The volumetric properties associated with protein folding transitions reflect changes in protein packing and hydration of the states that participate in the folding reaction. Here, NMR spin relaxation techniques are employed to probe the folding-unfolding kinetics of two SH3 domains as a function of pressure so that the changes in partial molar volumes along the folding pathway can be measured. The two domains...
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