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Adult Pancreatic Alpha-Cells: A New Source of Cells for Beta-Cell Regeneration

1 Jan 2010

Abstract excerpt

Beta-cell deficit is the major pathological feature in type 1 and type 2 diabetes patients, and plays a key role in disease progression. In principle, beta-cell regeneration can occur by replication of pre-existing beta-cells, or by beta-cell neogenesis from stem/progenitors. Unfortunately, beta-cell replication is limited by the almost complete absence of beta-cells in patients with type 1 diabetes, and the...

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PMID: 21060971
DOI: 10.1900/rds.2010.7.124

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