Article
Gene mutations in epidermal growth factor receptor signaling network and their association with survival in Chinese patients with metastatic colorectal cancers.
Anatomical record (Hoboken, N.J. : 2007) - 1 Sept 2010
Liao Wangjun, Liao Yulin, Zhou Jeff X, Xie Jianming, Chen Jinzhang, Huang Weizhen, Luo Rongcheng
Abstract excerpt
Mutations of the KRAS, BRAF, and PIK3CA genes have been reported in colorectal cancer (CRC), associated with resistance to epidermal growth factor receptor (EGFR)-targeted monoclonal antibody therapy. These reports have mainly emanated from Western countries, however, and little is known about the mutation frequencies of these genes and their prognostic value in Asian patients with CRC. In this study, we analyzed...
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