Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study.

doi:10.1186/s40880-017-0247-y

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Article

Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study.

Chinese journal of cancer - 16 Oct 2017

Wang Xicheng, Wei Qing, Gao Jing, Li Jian, Li Jie, Gong Jifang, Li Yanyan, Shen Lin

Abstract excerpt

BACKGROUND: The prognostic role of the V600E mutation of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) in metastatic colorectal cancer (mCRC) is well established, but the therapeutic regimen targeting this disease is lacking. This study aimed to analyze the clinicopathologic features of and treatment efficacy of commonly used regimens on BRAF-mutated mCRCs. METHODS: We collected and reviewed the medical...

Topics

Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Camptothecin
Colorectal Neoplasms
Female
Fluorouracil
Genes, ras
Humans
Kaplan-Meier Estimate
Leucovorin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Organoplatinum Compounds

Proto-Oncogene Proteins B-raf

Retrospective Studies

Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 29037218
DOI: 10.1186/s40880-017-0247-y
PMCID: PMC5644136

Genes

BRAF
KRAS
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29037218-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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