Article
Comparison of active vitamin D compounds and a calcimimetic in mineral homeostasis.
Journal of the American Society of Nephrology : JASN - 1 Oct 2010
Nguyen-Yamamoto Loan, Bolivar Isabel, Strugnell Stephen A, Goltzman David
Abstract excerpt
The differential effects between cinacalcet and active vitamin D compounds on parathyroid function, mineral metabolism, and skeletal function are incompletely understood. Here, we studied cinacalcet and active vitamin D compounds in mice expressing the null mutation for Cyp27b1, which encodes 25-hydroxyvitamin D-1α-hydroxylase, thereby lacking endogenous 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]....
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