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Article

Rescue of the phenotype of CYP27B1 (1alpha-hydroxylase)-deficient mice.

The Journal of steroid biochemistry and molecular biology - 1 May 2004

Dardenne Olivier, Prud'homme Josée, Glorieux Francis H, St-Arnaud René

Abstract excerpt

The treatment of choice for pseudo Vitamin D deficiency rickets (PDDR), caused by mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1; 1alpha-OHase) gene, is replacement therapy with 1,25(OH)(2)D(3). We have previously engineered an animal model of PDDR by targeted inactivation of the 1alpha-OHase gene in mice (Endocrinology 142 (2001) 3135). Replacement therapy was performed in this model, and...

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Identifiers

PMID: 15225794
DOI: 10.1016/j.jsbmb.2004.03.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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