Article
Effect of Roflumilast, a Selective PDE4 Inhibitor, on Bone Phenotypes in ADO2 Mice.
Calcified tissue international - 1 Apr 2024
Alam Imranul, Hardman Sara L, Gerard-O'Riley Rita L, Acton Dena, Parker Reginald S, Hong Jung Min, Bruzzaniti Angela, Econs Michael J
Abstract excerpt
Autosomal Dominant Osteopetrosis type II (ADO2) is a rare bone disease of impaired osteoclastic bone resorption that usually results from heterozygous missense mutations in the chloride channel 7 (CLCN7) gene. We previously created mouse models of ADO2 (p.G213R) with one of the most common mutations (G215R) as found in humans and demonstrated that this mutation in mice phenocopies the human disease of ADO2....
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