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Article

Purification of catalytically active caspase-12 and its biochemical characterization.

Archives of biochemistry and biophysics - 1 Oct 2010

Lee Hyun-Jung, Lee Sung Haeng, Park Sung-Hee, Sharoar M Golam, Shin Song Yub, Lee Jung Sup, Cho Byungyun, Park Il-Seon

Abstract excerpt

Caspase-12, mainly detected in endoplasmic reticulum (ER), has been suggested to play a role in ER-mediated apoptosis and inflammatory caspase activation pathway. Cleavage of the prodomain by caspase-3/-7 at the carboxyl terminus of Asp94 or m-calpain at the carboxyl terminus of Lys158 was reported to be a part of caspase-12-involved apoptosis. We biochemically characterized the prodomain-free forms of caspase-12...

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PMID: 20646990
DOI: 10.1016/j.abb.2010.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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