Article
Epo-C12 inhibits peroxiredoxin 1 peroxidase activity.
Bioorganic & medicinal chemistry - 1 Jul 2021
Yoda Tomoka, Furuta Masateru, Tsutsumi Tomohiko, Ikeda Seiki, Yukizawa Shunsuke, Arai Satoshi, Morita Akinori, Yamatoya Kenji, Nakata Kazuya, Tomoshige Shusuke, Ohgane Kenji, Furuyama Yuuki, Sakaguchi Kengo, Sugawara Fumio, Kobayashi Susumu, Ikekita Masahiko, Kuramochi Kouji
Abstract excerpt
Epo-C12 is a synthetic derivative of epolactaene, isolated from Penicillium sp. BM 1689-P. Epo-C12 induces apoptosis in human acute lymphoblastoid leukemia BALL-1 cells. In our previous studies, seven proteins that bind to Epo-C12 were identified by a combination of pull-down experiments using biotinylated Epo-C12 (Bio-Epo-C12) and mass spectrometry. In the present study, the effect of Epo-C12 on peroxiredoxin 1...
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