Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of lipid droplet turnover by ubiquitin ligases.

BMC biology - 19 Jul 2010

Alberts Philipp, Rotin Daniela

Abstract excerpt

Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Lipid Metabolism
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteins

Share to Spastic Paraplegia, Hereditary

Share to Ubiquitin-Protein Ligases

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 20646264
DOI: 10.1186/1741-7007-8-94
PMCID: PMC2906420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20646264-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of lipid droplet turnover by ubiquitin ligases.PMID 20646264Read ↗

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.Semantic proximity Read ↗

The Troyer syndrome protein spartin mediates selective autophagy of lipid dropletsSemantic proximity Read ↗

Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling.Semantic proximity Read ↗

Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformationSemantic proximity Read ↗

Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking.Semantic proximity Read ↗

Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.Semantic proximity Read ↗

DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chainsSemantic proximity Read ↗

A genetic screen to uncover molecular mechanisms underlying lipid transfer protein function at membrane contact sites and neurodegenerationSemantic proximity Read ↗

Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ.Semantic proximity Read ↗

Human WIPI β-propeller function in autophagy and neurodegeneration.Semantic proximity Read ↗

Studies on the autophagy gene WIPI4 and its interactor UBR5Semantic proximity Read ↗

The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.