Article

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets

2021-08-19

Abstract excerpt

Lipid droplets (LDs) are crucial organelles for energy storage and lipid homeostasis. Autophagy of LDs is an important pathway for their catabolism, but the molecular mechanisms mediating targeting of LDs for degradation by selective autophagy (lipophagy) are unknown. Here we identify spartin as a receptor localizing to LDs and interacting with core autophagy machinery, and we show that spartin is required to deli...

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Literature Corpus work: bcabe648-9806-5f47-bd9e-254a1db96136
DOI: 10.1101/2021.08.18.456894

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