Targeting of eEF1A with <i>Amaryllidaceae</i> isocarbostyrils as a strategy to combat melanomas

Abstract excerpt

ABSTRACT Melanomas display poor response rates to adjuvant therapies because of their intrinsic resistance to proapoptotic stimuli. This study indicates that such resistance can be overcome, at least partly, through the targeting of eEF1A elongation factor with narciclasine, an Amaryllidaceae isocarbostyril controlling plant growth. Narciclasine displays IC 50 growth inhibitory values between 30–100 nM in...

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